Ezh1 regulates expression of <i>Cpg15/Neuritin</i> in mouse cortical neurons

Immature neurons undergo morphological and physiological maturation in order to establish neuronal networks. During maturation, a large number of genes change their transcriptional levels, these changes may be mediated by chromatin modifiers. In this study, we found that the level Ezh1, component Polycomb repressive complex 2 (PRC2), increases during mouse neocortical culture. addition, conditional knockout Ezh1 post-mitotic excitatory leads downregulation set related maturation. Moreover, locus encoding Cpg15/Neuritin (Nrn1), which is regulated activity implicated stabilization synapses, direct target cortical neurons. Together, results suggest elevated expression contributes